Synthesen in der Isochinolinreihe Halogensubstituierte 1‐(ω‐Phenylalkyl)‐1,2,3,4‐tetrahydro‐isochinoline als Analgetica

Substituted 1‐methyl‐3,4‐dihydro‐isoquinolines can easily be converted to 2‐(β‐acylamido‐ethyl)‐acetophenomes. The latter have been used as intermediates for the synthesis of various substituted 1‐β‐phenylethyl‐2‐methyl‐1,2,3,4‐tetrahydro‐isoquinolines. Several of these compounds show interesting analgesic and spasmolytic properties, especially those containing a halogenated phenylethyl group.