Premium
Synthesen in der Isochinolinreihe Halogensubstituierte 1‐(ω‐Phenylalkyl)‐1,2,3,4‐tetrahydro‐isochinoline als Analgetica
Author(s) -
Brossi A.,
Besendrof H.,
Pellmont B.,
Walter M.,
Schinder O.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430603
Subject(s) - chemistry , stereochemistry , medicinal chemistry , organic chemistry
Substituted 1‐methyl‐3,4‐dihydro‐isoquinolines can easily be converted to 2‐(β‐acylamido‐ethyl)‐acetophenomes. The latter have been used as intermediates for the synthesis of various substituted 1‐β‐phenylethyl‐2‐methyl‐1,2,3,4‐tetrahydro‐isoquinolines. Several of these compounds show interesting analgesic and spasmolytic properties, especially those containing a halogenated phenylethyl group.