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Synthese eines Heptapeptides mit starker CRF‐Wirkung
Author(s) -
Kappeler H.,
Schwyzer R.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430602
Subject(s) - chemistry , sequence (biology) , in vitro , stereochemistry , biochemistry
The synthesis of the heptapeptide H · Met‐Glu(NH 2 )‐His‐Phe‐Arg‐Try‐Gly · OH (acetate) (VI) comprising the sequence of seven amino acid residues common to ACTH and α‐ and β‐MSH is described in detail. The compound shows a very weak MSH‐activity, no ACTH‐activity, but a very pronounced CRF‐activity (corticotropin releasing activity) in vitro .
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