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Recherches sur la formation et la transformation de dérivés organiques du fluor I. Préparation du fluoro‐1‐di‐hydroxyméthyl‐4,4‐pentane et de son dérivé dicarbamylé
Author(s) -
Cherbuliez Emile,
Baehler Br.,
Sussmann A. R.,
Rabinowitz J.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430424
Subject(s) - chemistry , medicinal chemistry , phosgene , pentane , stereochemistry , organic chemistry
The synthesis of 1‐fluoro‐4,4‐di‐hydroxymethyl‐pentane (I) and its dicarbamate (II) is described. (I) is obtained by classical alkylation of methylmalonic ester with 1‐ bromo‐3‐fluoro‐propane and subsequent reduction with LiAlH 4 , of the fluorinated diester obtained. Treated with phosgene and ammonia, the diol (I) yields the dicarbamate (II).