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Synthese von L ‐Arginyl‐ L ‐propyl‐ L ‐propyl‐glycyl‐ L ‐phenylalanyl‐ L ‐seryl‐ L ‐phenylalanyl‐ L ‐arginin (Bradykinin?). Vorläufige Mitteilung
Author(s) -
Schwyzer R.,
Rittel W.,
Sieber P.,
Kappeler H.,
Zuber H.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430423
Subject(s) - chemistry , bradykinin , hydrolysis , peptide , stereochemistry , biochemistry , receptor
For comparison with «snake‐venom bradykinin» 1 , the octapeptide H·Arg‐Pro‐Pro‐Gly‐Phe‐Ser‐Phe‐Arg·OH was synthesized (sequence proposed by E LLIOTT for «trypsin bradykinin» 4 . The synthetic product showed no bradykinin activity when tested on the isolated guinea‐pig ileum.