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Eine einfache Methode zur Herstellung von in Ring A ungesättigten 9, 11‐Dehydro‐16α‐methyl‐steroiden. Über Steroide, 162. Mitteilung
Author(s) -
Wieland P.,
Heusler K.,
Wettstein A.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430209
Subject(s) - chemistry , halogen , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , alkyl
A study of the reactions involved in the preparation of 16α‐methyl‐17α‐hydroxy‐21‐acetoxy‐Δ 1;4;9,11 ‐pregnatriene‐3, 20‐dione (V) from the corresponding 11α‐sulfonyloxy‐2,4‐dibromo‐allopregnane‐3,20‐diones led to a process in which all three substituents in 2‐, 4‐ and 11α‐positions are eliminated simultaneously. 2‐Halogen‐Δ 4;9,11 ‐pregnadiene‐3,20‐diones were formed as by‐products which were reduced to the halogen‐free dienes.