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Synthesen in der Polymyxin‐Reihe 2. Mitteilung. Synthese eines Dipeptid‐Fragmentes mit (+)‐Isopelargonsäure
Author(s) -
Vogler K.,
ChopardditJean L. H.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430137
Subject(s) - chemistry , polymyxin , dipeptide , stereochemistry , threonine , antibiotics , polymyxin b , peptide , combinatorial chemistry , organic chemistry , biochemistry , serine , enzyme
(+)‐6‐Methyloctanoic (isopelargonic) acid, the fatty acid component of certain polypeptide antibiotics known as polymyxins, has been synthesized by a new route, starting from (−)‐2‐methylbutanol‐(1). The protected dipeptide N α ‐(+)‐Isopelargonyl‐N γ ‐benzyloxycarbonyl‐ D ‐α,γ‐diaminobutyryl‐ L ‐threonine, corresponding to the side chain of two structures which have been proposed for polymyxin B 1 , was obtained by known peptide coupling methods.