Premium
Über die Konstitutionsermittlung und Synthese eines Metaboliten von N‐(γ‐Dimethylaminopropyl)‐iminodibenzyl‐hydrochlorid (Tofranil®)
Author(s) -
Schindler W.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430105
Subject(s) - chemistry , ethylenediamine , metabolite , medicinal chemistry , hydrochloride , yield (engineering) , ascorbic acid , stereochemistry , organic chemistry , biochemistry , materials science , metallurgy , food science
Oxidation of N‐(γ‐dimethylaminopropyl)‐iminodibenzyl hydrochloride (Tofranil®) with molecular oxygen in the presence of Fe 2+ salts, ethylenediamine‐tetraacetic acid and ascorbic acid leads to N‐(γ‐dimethylaminopropyl)‐2‐hydroxy‐iminodibenzyl in moderate yield. This product is identical with a metabolite of Tofranil® isolated from human urine.