Über die Konstitutionsermittlung und Synthese eines Metaboliten von N‐(γ‐Dimethylaminopropyl)‐iminodibenzyl‐hydrochlorid (Tofranil®) | Zendy

Schindler W. | Zendy

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Über die Konstitutionsermittlung und Synthese eines Metaboliten von N‐(γ‐Dimethylaminopropyl)‐iminodibenzyl‐hydrochlorid (Tofranil®)

Author(s) -

Schindler W.

Publication year - 1960

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19600430105

Subject(s) - chemistry , ethylenediamine , metabolite , medicinal chemistry , hydrochloride , yield (engineering) , ascorbic acid , stereochemistry , organic chemistry , biochemistry , materials science , metallurgy , food science

Oxidation of N‐(γ‐dimethylaminopropyl)‐iminodibenzyl hydrochloride (Tofranil®) with molecular oxygen in the presence of Fe 2+ salts, ethylenediamine‐tetraacetic acid and ascorbic acid leads to N‐(γ‐dimethylaminopropyl)‐2‐hydroxy‐iminodibenzyl in moderate yield. This product is identical with a metabolite of Tofranil® isolated from human urine.

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