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Sterische Einflüsse einer 16α‐Methylgruppe auf Reaktionen in der Seitenkette von Allopregnan‐Verbindungen
Author(s) -
Heusler K.,
Kebrle J.,
Meystre C.,
Ueberwasser H.,
Wieland P.,
Anner G.,
Wettstein A.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420636
Subject(s) - chemistry , yield (engineering) , ketone , furan , iodide , medicinal chemistry , side chain , stereochemistry , organic chemistry , materials science , metallurgy , polymer
The yield in the 1,4‐addition of methylmagnesium iodide to Δ 16 ‐allopregnene‐20 ones was improved by using tetrahydro‐furan as solvent, and the reaction was applied to a number of 11 ‐substituted and ‐unsubstituted compounds, to a Δ l6 ‐21‐acetoxy‐20‐ketone and also to 16‐dehydro‐progesterone.
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