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Über einige β‐substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 4. Mitteilung
Author(s) -
Smith A. E. Wilder
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420603
Subject(s) - chemistry , butyric acid , stereochemistry , derivative (finance) , medicinal chemistry , organic chemistry , economics , financial economics
The preparation and properties of some new β‐alkylamino‐butyric anilides have been described and a summary report on some of their pharmacological properties is given. Two derivatives (the p‐(carbo‐n‐butoxy)‐anilides of β‐diethylamino‐ and of β‐(1‐piperidino)‐ butyric acid = XVI and XVIII) show promise as very active local anaesthetics with low toxicities. One derivative (β‐N‐pyrrolidino‐n‐butyric acid anilide = XXVII) shows strong potentiation of the sedative properties of barbiturates.

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