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Temperaturabhängigkeit der Wirkung verschiedener Katalase‐Inhibitoren
Author(s) -
Gressly R.,
Aebi H.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420530
Subject(s) - chemistry , hydroxylamine , catalase , enzyme , formate , azide , medicinal chemistry , stereochemistry , nuclear chemistry , biochemistry , organic chemistry , catalysis
1 The inhibiting action at 0° and 37° C of a number of Catalase H‐Donors on the purified liver enzyme has been compared using F EINSTEIN 's perborate‐method. Furthermore the effect of enzyme preincubation with inhibitor has been investigated. 2 According to the dependency of the I 50 ‐values on temperature, the inhibitors can be divided in three groups; with the exception of 3‐Amino‐l,2,4‐triazole, they all inhibit the more the lower the temperature. This influence is pronounced in azide and formate; it is slight however in 2,4‐Dichlorphenol and Hydroxylamine. 3 Under certain conditions formate, acting as a stabilisor of complex I, does not inhibit but causes an apparent increase in catalatic activity.