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Eine neue Totalsynthese von d , l ‐Aldosteron Über Steroide, 158. Mitteilung
Author(s) -
Heusler K.,
Wieland P.,
Wettstein A.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420521
Subject(s) - chemistry , aldosterone , total synthesis , derivative (finance) , stereochemistry , hydrolysis , ether , organic chemistry , medicine , financial economics , economics
A new total synthesis of d , l ‐aldosterone‐21‐mono‐O‐acetate is described. It starts from the dodecahydro‐phenanthrene derivative I and the main synthetic pathway is indicated in the formula schemes by bold arrows. The ketalised oxo group in position 3 and the tetrahydro‐pyranyl ether of the 18,11β‐cyclohemiacetal could be preserved throughout the synthesis, and these protecting groups were simultaneously hydrolysed in the last step.