Eine neue Totalsynthese von  d , l ‐Aldosteron   Über Steroide, 158. Mitteilung | Zendy

Heusler K. | Zendy; Wieland P. | Zendy; Wettstein A. | Zendy

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Eine neue Totalsynthese von d , l ‐Aldosteron Über Steroide, 158. Mitteilung

Author(s) -

Heusler K.,

Wieland P.,

Wettstein A.

Publication year - 1959

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19590420521

Subject(s) - chemistry , aldosterone , total synthesis , derivative (finance) , stereochemistry , hydrolysis , ether , organic chemistry , medicine , financial economics , economics

A new total synthesis of d , l ‐aldosterone‐21‐mono‐O‐acetate is described. It starts from the dodecahydro‐phenanthrene derivative I and the main synthetic pathway is indicated in the formula schemes by bold arrows. The ketalised oxo group in position 3 and the tetrahydro‐pyranyl ether of the 18,11β‐cyclohemiacetal could be preserved throughout the synthesis, and these protecting groups were simultaneously hydrolysed in the last step.

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