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Hemmung der Bernsteinsäure‐Cytochrom‐c‐Reduktase und deren Reaktivierung durch isoprenartige Verbindungen
Author(s) -
Weber F.,
Wiss O.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420425
Subject(s) - chemistry , side chain , bromine , reductase , stereochemistry , cytochrome , medicinal chemistry , organic chemistry , enzyme , polymer
Isooctane and other hydrocarbons inhibit the succinic‐cytochrome c reductase of a mitochondria preparation. This inhibition is not only due to the lipid solubility of these substances, but is caused, moreover, by other structural properties. A distinct dependence on the length of the side‐chain has been observed. Side‐chains with 6 to 7 carbon atoms are the most active ones. Introduction of a hydroxyl group into the n‐alkanes decreases the inhibitory effect, whereas it is increased by bromine substitution.