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Über Dibenzo‐thiazepin‐Derivate und ihre pharmakologische Wirkung
Author(s) -
Jaques R.,
Rossi A.,
Urech E.,
Bein H. J.,
Hoffmann K.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420422
Subject(s) - chemistry , antihistamine , stereochemistry , medicinal chemistry , pharmacology , medicine
The synthesis and pharmacological activity of basically substituted dibenzothiazepines are described. They possess interesting antihistamine and antiserotonine activity. By varying the substituents in the benzene nuclei, and by a suitable choice the basic side chains, the specifity and activity of some derivatives could be increased considerably, especially with the dibenzothiazepinones.