Die Glykoside der Samen von Nerium oleander L. . Glykoside und Aglykone, 200. Mitteilung

By the use of absorption, partition and paper chromatography as well as counter‐current distribution 18 pure crystalline cardenolides (B, γ, C, δ, D, E, F, G, H, I, K, L N, 0, P, π, ς and Q) and a further crystalline KEDDE‐positive compound (A) were isolated after fermentation of the seeds of Nerium oleaizder L. The compounds H, I and e were identified with known genins; namely Digitoxigenin (H), Oleandrigenin (I) and Gitoxigenin (ς). Of the remaining 15 compounds, 14 were found to be glycosides composed of the 4 genins H, I, ς and 16‐Anhydro‐gitoxigenin with the following sugars: L ‐Oleandrose, D ‐Diginose, D ‐Samentose and D ‐Digidose. 10 of these glycosides have previously been isolated in pure form. They are: Digistroside (γ), Oleandrin (C), Cryptograndoside A (d), 16‐Anhydro‐desacetyl‐cryptograndoside A (D), Odoroside A (E), Desacetyl‐oleandrin (K), Desacetyl‐cryptograndoside A (L), Odoroside H (0), 16‐Anhydro‐strospeside (n) and Strospeside (Q). The other 4 are new compounds whose structures were elucidated and which were named as follows: Nerigoside (F), 16‐Anhydro‐desacetyl‐nerigoside (G), Desacetyl‐nerigoside (N) and Neritaloside (P).