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Die Reaktivierung der Bernsteinsäure‐Cytochrom‐c‐Reduktase durch die Vitamine K 1 und K 2 und deren Isoprenologen
Author(s) -
Weber F.,
Wiss O.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420120
Subject(s) - chemistry , side chain , stereochemistry , vitamin , reductase , enzyme , biochemistry , organic chemistry , polymer
Vitamin K 1 and its analogues with 5, 10, 15, 25 and 30 C‐atoms in the side‐chain, and the isoprenologues of the vitamin K 2 series with side‐chains of 10 to 35 C‐atoms, have been tested comparatively as regards their reactivation effect on succinate‐cytochrome‐c reductase, inactivated by isooctane. This reactivation depends clearly on the length of the side‐chain, in the vitamin K 1 as well as in the vitamin K 2 series. In both series the most active substances are those with a side‐chain of 25 C‐ atoms. Shortening of the side‐chain is parallelled with a heavy decrease of the activity, while the analogues of the vitamins K 1 and K 2 with 30 or 35 C‐atoms in the side‐chain lose their activity only to a slight degree.