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Heilmittelchemische Studien in der heterocyclischen Reihe. 23. Mitteilung. Pyridazine XI. Die Reaktion von Kojisäure mit Hydrazin. 1. Teil
Author(s) -
Thomas A. F.,
Marxer A.
Publication year - 1958
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19580410645
Subject(s) - chemistry , pyridazine , hydrazine (antidepressant) , kojic acid , medicinal chemistry , hydrate , hydrazone , organic chemistry , chromatography , tyrosinase , enzyme
It has been shown that the reaction between kojic acid and hydrazine hydrate gives rise to two main products: 3,6‐dihydroxymethyl‐4‐oxo‐1,4‐dihydro‐pyridazine, and the hydrazone of 3‐hydroxymethyl‐pyrazol‐5‐yl‐hydroxyacetaldehyde, the structures of which were proved unambiguously.