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Synthese hochwirksamer Oktapeptide mit der vermutlichen Aminosäuresequenz des noch unbekannten Hypertensins II aus Rinderserum (Val 5 ‐Hypertensin II und Val 5 ‐Hypertensin II‐Asp‐β‐amid)
Author(s) -
Schwyzer R.,
Iselin B.,
Kappeler H.,
Riniker B.,
Rittel W.,
Zuber H.
Publication year - 1958
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19580410513
Subject(s) - chemistry , stereochemistry
The synthesis of two octapeptides, H · Asp(β‐NH 2 )‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH and H · Asp(β‐OH)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, is described in detail (preliminary communications see footnote 3). The products show a very strong hypertensive activity, and may be identical with the hitherto unknown Val 5 ‐hypertensin II of ox blood.