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Totalsynthese des Aldosterons. C. Racemisches Aldosteron und die beiden Enantiomeren des entsprechenden (18 → 11)‐Lactons. Über Steroide, 149. Mitteilung
Author(s) -
Schmidlin J.,
Anner G.,
Billeter J.R.,
Heusler K.,
Ueberwasser H.,
Wieland P.,
Wettstein A.
Publication year - 1957
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19570400729
Subject(s) - chemistry , stereochemistry , lactone
A detailed description is presented of the conversion of the racemic pregnene lactone I into d ,l‐aldosterone (XXVIII). In addition a physico‐chemical procedure for the optical resolution of the intermediate acid VI is given, leading to the preparation of the ketol d ‐XV, which was transformed earlier into d ‐aldosterone( 28 ).