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Synthesen des 4‐Amino‐3‐isoxazolidinons (Cycloserin) und einiger Analoga
Author(s) -
Plattner Pl. A.,
Boller A.,
Frick H.,
Fürst A.,
Hegedüs B.,
Kirchensteiner H.,
Maji St.,
Schläpfer R.,
Spiegelberg H.
Publication year - 1957
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19570400536
Subject(s) - chemistry , amino acid , stereochemistry , stereospecificity , cycloserine , organic chemistry , biochemistry , antibiotics , catalysis
Stereospecific syntheses of cycloserine ( D ‐4‐amino‐3‐isoxazolidinone) are described. The same synthetic methods lead to some 5‐substituted 4‐amino‐3‐isoxazolidinones. The stereochemical relationship of these compounds to the parent amino acids is discussed.