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Synthese eines hochwirksamen Hypertensin II‐amids ( L ‐Asparaginyl‐ L ‐arginyl‐ L ‐valyl‐ L ‐tyrosyl‐ L ‐isoleucyl‐ L ‐histidyl‐ L ‐prolyl‐ L ‐phenylalanin)
Author(s) -
Rittel W.,
Iselin B.,
Kappeler H.,
Riniker B.,
Schwyzer R.
Publication year - 1957
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19570400317
Subject(s) - chemistry , amide , peptide , biochemistry , stereochemistry
The synthesis of Ileu 5 ‐hypertensin II‐Asp‐β‐amide, L ‐Asparaginyl‐ L ‐arginyl‐ L ‐valyl‐ L ‐tyrosyl‐ L ‐isoleucyl‐ L ‐histidyl‐ L ‐prolyl‐ L ‐phenylalanine, is described. The highly purified octapeptide is 5 to 10 times as active as noradrenaline on the blood pressure of the rat in the experimental set‐up of Peart 9 ), and 2 to 4 times as active as Val 5 ‐ hypertensin I, isolated from bovine plasma 3 ).