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Über Derivate des Phenylbutazons. II. Derivate mit einer Hydroxylgruppe in der 4‐ständigen Seitenkette
Author(s) -
Denss R.,
Häfliger F.,
Goodwin Sidney
Publication year - 1957
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19570400219
Subject(s) - chemistry , phenylbutazone , side chain , stereochemistry , organic chemistry , medicine , pharmacology , polymer
The synthesis of three derivatives of phenylbutazone with a hydroxy group in the butyl side chain is described, among them γ‐hydroxy‐phenylbutazone [1, 2‐diphenyl‐4‐(γ‐hydroxy‐n‐butyl)‐pyrazolidine‐3,5‐dione] (IV), the laevo‐rotatory isomer of which is one of the metabolites of phenylbutazone in man.