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Isolierung und Konstitutionsermittlung weiterer Pregnanverbindungen aus Nebennieren. Über Steroide, 144. Mitteilung
Author(s) -
Neher R.,
Wettstein A.
Publication year - 1956
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19560390719
Subject(s) - chemistry , stereochemistry , hydroxylation , pregnane , aldehyde , medicinal chemistry , organic chemistry , enzyme , catalysis
Nine additional compounds of the pregnane series have been isolated from adrenals. Elucidation of their constitution showed that four are known compounds, but five are new. They are derived from the classical corticoids by hydroxylation in the 6β‐ or 19‐positions, by reduction of the 4,5‐double bond or 20‐keto group, and by oxydation of the angular 18‐methyl group not merely to an aldehyde, as in aldosterone, but to a carboxyl group. The latter derivative is of special biochemical interest.