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Spontane Spaltung von 2,4‐Dioxo‐3,3‐diäthyl‐5‐methyl‐piperidin in die optischen Antipoden
Author(s) -
Vogler K.,
Kofler M.
Publication year - 1956
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19560390526
Subject(s) - chemistry , piperidine , acetone , methanol , medicinal chemistry , melting point , stereochemistry , organic chemistry
Abstract 2, 4‐Dioxo‐3, 3‐diethyl‐5‐methyl‐piperidine is spontaneously re‐ solved into its optical antipodes by about 400 crystallisations from various solvents e.g. methanol, acetone, butanol, water etc. From the melting point diagram and the behaviour in the resolution process it must be concluded that its optical antipodes form mixed crystals. Racemixation rates of the optically active material in various solvents are reported. (+)‐2, 4‐Dioxo‐3, 3‐diethyl‐5‐methyl‐piperidine is a little more active as a hypnotic than its (−)‐antipode.