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Heilmittelchemische Untersuchungen in der heterocyclischen Reihe. Mitteilung. Pyrazolo‐(3,4‐d)‐pyrimidine
Author(s) -
Schmidt P.,
Druey J.
Publication year - 1956
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19560390345
Subject(s) - chemistry , pyrimidine , medicinal chemistry , stereochemistry
The synthesis of 4‐ and 6‐substituted 1‐H‐ and 1‐phenyl‐pyrazolo‐(3,4‐d)‐pyrimidines is described. It starts from ethyl ethoxymethylene cyanoacetate from which the 4‐hydroxy‐pyrazolo‐(3,4‐d)‐ pyrimidines can be obtained in two steps through the corresponding 2‐substituted 3‐amino‐4‐carbethoxy‐pyrazoles.