Premium
Hydroxy‐morphinane. 7. Mitteilung. (−)‐3‐Hydroxy‐N‐allyl‐morphinan und verwandte Verbindungen
Author(s) -
Hellerbach J.,
Grüssner A.,
Schnider O.
Publication year - 1956
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19560390212
Subject(s) - chemistry , isoquinoline , nitrogen atom , stereochemistry , optically active , medicinal chemistry , organic chemistry , ring (chemistry)
1‐(p‐Hydroxybenzyl)‐1, 2,3,4,5,6,7,8‐octahydro‐isoquinoline has been resolved into the optical antipodes, from which any desired optically active 3‐hydroxy‐morphinan substituted at the nitrogen atom can easily be obtained. The (‐)‐3‐hydroxy‐N‐allyl‐morphinan thus obtained as well as its ethers and ester counteract the effect of opiates and other potent narcotics. Given in adequate small doses they are able to relieve undesirable side effects.