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Über aktivierte Ester VI. Tetrahydro‐pyranyl‐Derivate von Aminosäuren und ihre Umsetzungen
Author(s) -
Iselin B.,
Schwyzer R.
Publication year - 1956
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19560390108
Subject(s) - chemistry , serine , residue (chemistry) , hydrolysis , amino acid , tyrosine , organic chemistry , enzyme , biochemistry
Whereas the usefulness of the tetrahydro‐pyranyl residue for the activation of esters is rather limited, it is of definite value for the temporary etherification of the hydroxyl groups of tyrosine and serine derivatives. The stability of tetrahydro‐pyranyl ethers towards alkali and the rapid hydrolysis by acids permit a great variety of transformations of these amino acid derivatives. The only disadvantage adherent to the use of the tetrahydro‐pyranyl group is the introduction of a new asymmetric center.