Premium
Über einige β‐substituierte Fettsäureamide mit lokalanästhetischer Wirkung
Author(s) -
Wilder Smith A. E.,
Hofstetter Emil
Publication year - 1955
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19550380502
Subject(s) - chemistry , medicinal chemistry
The preparation and properties of further fatty acid anilides showing anaesthetic action are described and the relationship between chemical constitution and physiological effect is discussed. Two very active compounds having relatively low toxicities have been discovered, namely:‐ β‐piperidino‐n‐butyric‐acid‐2,4‐dichloranilide (XIV) and β‐(2‐methylpiperidino)‐n‐butyric‐acid‐anilide (V). A number of similar anilides show high activities, but other undesirable properties such as tissue irritation render them less useful.