Mikrobiologische Hydroxylierungen von Cortexon in der 7α‐, 15α‐ oder 15β‐Stellung. Mikrobiologische Reaktionen, 5. Mitteilung

In continuation of our earlier work certain fungi were detected which are capable of hydroxylating steroids at further carbon atoms of the nucleus. These microbiological procedures have made possible the preparation of new cortexone derivatives with an additional hydroxyl group in 7α‐, 15α‐ or 15β‐position. The elucidation of the constitution of these compounds by degradation and chemical connection with known steroids has been accomplished. From the molecular rotation differences observed the configuration of 2α, 3β, 15α‐trihydroxy‐5α, 22 a‐spirostane is suggested for digitogenin.