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Eine pasteurisierbare humane Plasmaproteinlösung (PPL), erhalten durch Entsalzung von Plasma mittels Ionenaustauschern
Author(s) -
Nitschmann Hs.,
Kistler P.
Publication year - 1954
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19540370622
Subject(s) - chemistry , isotonic , chromatography , ion exchange , sodium , ion , organic chemistry , medicine
Abstract Human plasma or serum is desalted completely by passing through a column containing a suitable mixture of an anion exchanger (OH − cycle) and a cation exchanger (H + cycle). At the resulting very low ionic strength and pH 5.2 part of the globulins is precipitated. The solution is neutralized. A stabilizer such as sodium caprylate and glucose if necessary to make an isotonic solution are added. Then the solution is filtered through a bacterial filter into the final containers. It can be pasteurized for 10 hours at 60° C without clotting, a treatment known to kill the homologous serum hepatitis virus which is frequently present in pooled plasma.