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Mikrobiologische Hydroxylierung von Steroiden in der 17α‐ und 21‐Stellung. Mikrobiologische Reaktionen, 4. Mitteilung
Author(s) -
Meystre Ch.,
Vischer E.,
Wettstein A.
Publication year - 1954
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19540370523
Subject(s) - chemistry , cortisone , corticosterone , steroid , stereochemistry , biochemistry , endocrinology , biology , hormone
Some fungi, especially strains of the genus Trichothecium were found to be able of introducing a hydroxy group into the 17 α‐position of the steroid molecule. By means of this microbiological process, cortexone was converted into 17 α‐hydroxy‐cortexone ( Reichstein's substance S), 11‐dehydro‐corticosterone into cortisone, and finally corticosterone into 17 α‐hydroxy‐corticosterone (hydrocortisone) and cortisone.