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Über eine biologische Bedeutung der Gallenfarbstoffe. Bilirubin und Biliverdin als Antioxydantien für das Vitamin A und die essentiellen Fettsäuren
Author(s) -
Bernhard Karl,
Ritzel Günther,
Steiner K. U.
Publication year - 1954
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19540370139
Subject(s) - chemistry , bile pigments , bilirubin , biliverdin , vitamin , in vivo , vitamin e , taurocholic acid , biochemistry , pharmacology , bile acid , antioxidant , medicine , pigment , enzyme , heme , heme oxygenase , microbiology and biotechnology , organic chemistry , biology
Rats with a thoracic duct fistula absorb vitamin A and β‐carotene very poorly in the total absence of bile from the intestine. Administration of taurocholic acid improves the degree of absorption but fails to raise it to its normal level. It was demonstrated in vitro that small quantities of bilirubin and biliverdin exert a stabilizing action towards vitamin A. Consequently, it may be assumed that the bile pigments play the same role in vivo, serving as natural antioxidants which protect easily oxidizable substances from destruction in the intestinal tract.