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Über Alkylenimin‐Derivate. 5. Mitteilung. Synthese einiger 3‐Aryl‐3‐oxy‐piperidine
Author(s) -
Iselin B. M.,
Hoffmann K.
Publication year - 1954
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19540370121
Subject(s) - chemistry , hydrogenolysis , piperidine , aryl , catalysis , stereochemistry , medicinal chemistry , organic chemistry , alkyl
The synthesis of N‐benzyl‐3‐piperidone and its conversion to N‐benzyl‐3‐aryl‐3‐hydroxy‐piperidines is described. On catalytic debenzylation the derivatives with a free hydroxyl group show a normal behaviour whereas the O‐acylated derivatives loose the acyloxy group as a result of hydrogenolysis.
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