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Über die Herstellung und physiologischen Eigenschaften einiger Acetylenverbindungen und verwandter Stoffe. 2. Mitteilung. Über die Umlagerung von 3,4‐Di‐p‐anisyl‐3‐ol‐hexin‐(1)
Author(s) -
Hofstetter Emil,
Smith A. E. Wilder
Publication year - 1953
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19530360734
Subject(s) - chemistry , medicinal chemistry
Attempts to remove water from 3,4‐di‐p‐anisyl‐1‐hexyn‐3‐ol in acid medium resulted in rearrangement according to Meyer ‐ Schuster principally and to Rupe to a minor extent. None of the derivatives of these rearrangement products reached the oestrogenicity of stilboestrol. The dehydration of 3,4‐di‐p‐anisyl‐3‐hexen‐2‐ol does not lead to the expected diene but to the corresponding methylether of the known 1‐ethyl‐2‐p‐hydroxyphenyl‐3‐methyl‐5‐hydroxyindene.