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Über Steroide. 118. Mitteilung. Ein neues Verfahren zur Herstellung von Steroiden mit 11β‐Hydroxylgruppe. I. Versuche an Verbindungen der Spirostanreihe
Author(s) -
Schmidlin J.,
Wettstein A.
Publication year - 1953
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19530360604
Subject(s) - chemistry , stereochemistry , medicinal chemistry
A simple five‐step conversion of 12‐ketosteroids into 11 β‐hydroxy compounds (and also 11‐ketones) through 11 β, 12 β‐epoxides is described. The process can be accomplished with high yields, as it is shown in the present paper dealing with the application to hecogenin acetate.