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Über Alkylenimin‐Derivate. 1. Mitteilung. Über in 3‐Stellung basisch substituierte Pyrrolidin‐, Piperidin‐ und Hexamethylenimin‐Derivate
Author(s) -
Tagmann E.,
Sury E.,
Hoffmann K.
Publication year - 1952
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19520350420
Subject(s) - chemistry , piperidine , saponification , acrylonitrile , pyrrolidine , acetic acid , ring (chemistry) , organic chemistry , medicinal chemistry , polymer , copolymer
3:3‐Disubstituted 2,6‐dioxo‐piperidine derivatives can be prepared by means of a Michael condensation of disubstituted acetic acid nitriles or acetic acid esters with acrylonitrile or acrylic acid esters, followed by saponification and ring closure. Of the aminoalkylated phenyl‐dioxo‐piperidines described the 3‐diethylamino‐ethyl‐3‐phenyl‐2,6‐dioxo‐piperidine has an especially strong and specific parasympathicolytic action. For purposes of comparison some pyrrolidine and hexamethyleneimine compounds were also prepared.