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Multideterminant role of calcium in hippocampal synaptic plasticity
Author(s) -
Teyler Timothy J.,
Cavus I.,
Coussens C.,
Discenna P.,
Grover L.,
Lee Y. P.,
Little Z.
Publication year - 1994
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.450040602
Subject(s) - neuroscience , synaptic plasticity , metaplasticity , hippocampal formation , nonsynaptic plasticity , synaptic scaling , synaptic fatigue , synaptic augmentation , plasticity , neuroplasticity , homosynaptic plasticity , hippocampus , chemistry , psychology , excitatory postsynaptic potential , physics , receptor , biochemistry , thermodynamics , inhibitory postsynaptic potential
Hippocampal CA1 cells possess several varieties of long‐lasting synaptic plasticity: two different forms of long‐term potentiation (LTP) and at least one form of long‐term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca 2+ influx, all can be blocked by Ca 2+ chelators, and all activate Ca 2+ ‐dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage‐dependent differences in cytosolic Ca 2+ concentration acting upon Ca 2+ substrates of differing Ca 2+ affinities and compartmentalization of the Ca 2+ and its substrates. © 1994 Wiley‐Liss, Inc.