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Ultrastructural identification of entorhinal cortical synapses in CA1 stratum lacunosum‐moleculare of the rat
Author(s) -
Desmond Nancy L.,
Scott Carol A.,
Jane John A.,
Levy William B.
Publication year - 1994
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.450040509
Subject(s) - dendritic spine , axon , synapse , postsynaptic potential , neuroscience , hippocampal formation , fascia dentata , hippocampus , chemistry , entorhinal cortex , biology , anatomy , dentate gyrus , biochemistry , receptor
The goal of the present study was to identify and characterize, at the electron microscopic level, the synapses formed by entorhinal cortical (EC) axons in the hippocampal CA1 stratum lacunosummoleculare of the adult rat. Phaseolus vulgaris leucoagglutinin was ionotophoresed at various loci throughout the mediolateral and dorsoventral extent of the EC to label EC‐CA1 synapses. Virtually all labeled synapses were asymmetric and axospinous. EC axons did not preferentially synapse with any particular type of dendritic spine; rather, EC axons formed synapses with the range of dendritic spine morphologies observed in CA1 s. lacunosum‐moleculare. Spines with either perforated or nonperforated postsynaptic densities were contacted by EC axons. Occasionally both a labeled and an unlabeled axon synapsed on a single dendritic spine head. The data are discussed in relation to the morphology of other afferent systems synapsing in s. lacunosum‐moleculare and to the physiology of the EC‐CA1 system. © 1994 Wiley‐Liss, Inc.