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Effects of medial septal or unilateral hippocampal inactivations on reference and working spatial memory in rats
Author(s) -
Poucet B.,
Buhot M.C.
Publication year - 1994
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.450040315
Subject(s) - hippocampal formation , neuroscience , psychology , hippocampus , working memory , cognitive psychology , cognition
The memory performances of rats receiving a reversible inactivation of either the medial septum or one side of the ventral hippocampus were compared in a radial arm maze task allowing the assessment of both working and reference memory. After pre‐surgery training, rats were chronically equipped with bilateral cannulae into the ventral hippocampus and a single cannula into the medial septum. Following post‐surgery retraining, animals received a series of test trials during which they received saline or lidocaine injections in either the medial septum or one side of the ventral hippocampus. Lidocaine injections in either structure resulted in both reference and working memory deficits. However, animals were more impaired after septal injections than after unilateral hippocampal injections. This result suggests that the septo‐hippocampal formation acts as a functionally homogeneous structure essential for spatial processing. © 1994 Wiley‐Liss, Inc.