Premium
Selective neuromodulation and mutual inhibition within the CA3–CA2 system can prioritize sequences for replay
Author(s) -
Stöber Tristan M.,
Lehr Andrew B.,
Hafting Torkel,
Kumar Arvind,
Fyhn Marianne
Publication year - 2020
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.23256
Subject(s) - neuromodulation , neuroscience , hippocampal formation , neural activity , perspective (graphical) , computer science , variety (cybernetics) , biology , artificial intelligence , central nervous system
To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory‐gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.