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The role of the hippocampus in the semantic variant of primary progressive aphasia: A resting‐state fcMRI study
Author(s) -
Chapleau Marianne,
Montembeault Maxime,
Boukadi Mariem,
Bedetti Christophe,
Laforce Robert,
Wilson Maximiliano,
Brambati Simona M.
Publication year - 2019
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.23156
Subject(s) - primary progressive aphasia , hippocampus , neuroscience , psychology , semantic memory , hippocampal formation , disconnection , aphasia , resting state fmri , medicine , frontotemporal dementia , pathology , cognition , dementia , disease , political science , law
Abstract The goal of the study was to determine whether the semantic variant of primary progressive aphasia (svPPA) affects the intrinsic connectivity network anchored to left and right anterior hippocampus, but spares the posterior hippocampus. A resting‐state functional connectivity MRI (rs‐fcMRI) study was conducted in a group of patients with svPPA and in controls, using a seed‐to‐voxel approach. In comparison to controls, massively reduced connectivity was found in the anterior hippocampus, mainly the left one, for svPPA patients but not in the left or right posterior hippocampus. In svPPA, the anterior hippocampus showed reduced functional connectivity with regions implicated in the semantic memory network. Significant correlation was also found between the functional connectivity strength of the left anterior hippocampus and the ventromedial cortex, and performance in semantic tasks. These findings indicate that the functional disconnection of the anterior hippocampus may be a promising in vivo biomarker of svPPA and illustrate the role of this hippocampal subregion in the semantic memory system.