z-logo
Premium
White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy
Author(s) -
Fiford Cassidy M.,
Manning Emily N.,
Bartlett Jonathan W.,
Cash David M.,
Malone Ian B.,
Ridgway Gerard R.,
Lehmann Manja,
Leung Kelvin K.,
Sudre Carole H.,
Ourselin Sebastien,
Biessels Geert Jan,
Carmichael Owen T.,
Fox Nick C.,
Cardoso M. Jorge,
Barnes Josephine
Publication year - 2017
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22690
Subject(s) - hyperintensity , neuroscience , hippocampal formation , atrophy , white matter , psychology , audiology , medicine , magnetic resonance imaging , pathology , radiology
ABSTRACT This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with serial volumetric 1.5‐T MRI. CSF Aβ 42 and total tau were measured ( n = 353). Brain and hippocampal loss were quantified from serial MRI using the boundary shift integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates. Models were refitted adjusting for (a) concurrent brain/hippocampal atrophy rates and (b) CSF Aβ 42 and tau in subjects with CSF data. WMH burden was positively associated with hippocampal atrophy rate in controls ( P = 0.002) and MCI subjects ( P = 0.03), and with brain atrophy rate in controls ( P = 0.03). The associations with hippocampal atrophy rate remained following adjustment for concurrent brain atrophy rate in controls and MCIs, and for CSF biomarkers in controls ( P  = 0.007). These novel results suggest that vascular damage alongside AD pathology is associated with disproportionately greater hippocampal atrophy in nondemented older adults. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here