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RB regulates the production and the survival of newborn neurons in the embryonic and adult dentate gyrus
Author(s) -
Vandenbosch Renaud,
Clark Alysen,
Fong Bensun C.,
Omais Saad,
Jaafar Carine,
DugalTessier Delphie,
Dhaliwal Jagroop,
Lagace Diane C.,
Park David S.,
Ghanem Noël,
Slack Ruth S.
Publication year - 2016
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22613
Subject(s) - dentate gyrus , neuroscience , embryonic stem cell , gyrus , psychology , hippocampus , biology , gene , genetics
In mammals, hippocampal dentate gyrus granule cells (DGCs) constitute a particular neuronal population produced both during embryogenesis and adult life, and play key roles in neural plasticity and memory. However, the molecular mechanisms regulating neurogenesis in the dentate lineage throughout development and adulthood are still not well understood. The Retinoblastoma protein (RB), a transcriptional repressor primarily involved in cell cycle control and cell death, plays crucial roles during cortical development but its function in the formation and maintenance of DGCs remains unknown. Here, we show that loss of RB during embryogenesis induces massive ectopic proliferation and delayed cell cycle exit of young DGCs specifically at late developmental stages but without affecting stem cells. This phenotype was partially counterbalanced by increased cell death. Similarly, during adulthood, loss of RB causes ectopic proliferation of newborn DGCs and dramatically impairs their survival. These results demonstrate a crucial role for RB in the generation and the survival of DGCs in the embryonic and the adult brain. © 2016 Wiley Periodicals, Inc.