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CBP ‐Dependent memory consolidation in the prefrontal cortex supports object‐location learning
Author(s) -
Vieira Philip A.,
Korzus Edward
Publication year - 2015
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22473
Subject(s) - neuroscience , prefrontal cortex , spatial memory , hippocampus , memory consolidation , psychology , long term memory , explicit memory , hippocampal formation , effects of stress on memory , long term potentiation , recall , episodic memory , working memory , cognition , cognitive psychology , chemistry , receptor , biochemistry
Recognition of an object's location in space is supported by hippocampus‐dependent recollection. Converging evidence strongly suggests that the interplay between the prefrontal cortex and hippocampus is critical for spatial memory. Lesion, pharmacological, and genetic studies have been successful in dissecting the role of plasticity in the hippocampal circuit in a variety of neural processes relevant to spatial memory, including memory for the location of objects. However, prefrontal mechanisms underlying spatial memory are less well understood. Here, we show that an acute hypofunction of the cyclic‐AMP regulatory element binding protein (CREB) Binding Protein (CBP) histone acetyltransferase (HAT) in the medial prefrontal cortex (mPFC) results in delay‐dependent disruption of object‐location memory. These data suggest that mechanisms involving CBP HAT‐mediated lysine acetylation of nuclear proteins support selectively long‐term encoding in the mPFC circuits. Evidence from the object‐location task suggests that long‐term memory encoding within the mPFC complements hippocampus‐dependent spatial memory mechanisms and may be critical for broader network integration of information necessary for an assessment of subtle spatial differences to guide appropriate behavioral response during retrieval of spatial memories. © 2015 Wiley Periodicals, Inc.