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The role of postnatal neurogenesis in supporting remote memory and spatial metric processing
Author(s) -
Kesner Raymond P.,
Hui Xu,
Sommer Taylor,
Wright Casey,
Barrera Vanessa R.,
Fanselow Michael S.
Publication year - 2014
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22346
Subject(s) - neurogenesis , neuroscience , metric (unit) , psychology , computer science , economics , operations management
In this study, we determined the contribution of juvenile neurogenesis to the performance of mice on a remote memory for temporally based association task and in a novelty based spatial pattern separation task. This was accomplished by mating homozygous DNMT1‐loxP mice with heterozygous GFAP‐Cre mice and comparing Cre+ (no postnatal neurogenesis) to Cre− (wild type) littermate offspring. The results indicate that Cre+ mice are impaired relative to Cre− mice in the remote memory for a temporal based association task and in a novelty based spatial pattern separation task. These results support the temporal integration model of Aimone et al., [(2006) Nat Neurosci 9:723–727] and provide further support for an important role for postnatally born neurons in spatial pattern separation. In contrast, Cre+ mice are not impaired relative to Cre− mice in an object‐context recognition task and a spatial location recognition task. These latter data suggest that postnatally derived neurons in the dentate gyrus (DG) do not support all spatial and object recognition functions of the DG. © 2014 Wiley Periodicals, Inc.