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Exercise boosts hippocampal volume by preventing early age‐related gray matter loss
Author(s) -
Fuss Johannes,
Biedermann Sarah V.,
FalfánMelgoza Claudia,
Auer Matthias K.,
Zheng Lei,
Steinle Jörg,
Hörner Felix,
Sartorius Alexander,
Ende Gabriele,
WeberFahr Wolfgang,
Gass Peter
Publication year - 2014
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22227
Subject(s) - hippocampal formation , neurogenesis , neuroscience , neuroplasticity , brain morphometry , hippocampus , voxel , voxel based morphometry , magnetic resonance imaging , psychology , gray (unit) , medicine , nuclear medicine , white matter , radiology
Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel‐based morphometry revealed that running increases hippocampal volume by inhibiting an early age‐related gray matter loss. Disruption of neurogenesis‐related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology. © 2013 Wiley Periodicals, Inc.