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The effect of acute swim stress and training in the water maze on hippocampal synaptic activity as well as plasticity in the dentate gyrus of freely moving rats: Revisiting swim‐induced LTP reinforcement
Author(s) -
Tabassum Heena,
Frey Julietta U.
Publication year - 2013
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22166
Subject(s) - long term potentiation , neuroscience , dentate gyrus , hippocampal formation , excitatory postsynaptic potential , synaptic plasticity , hippocampus , ltp induction , psychology , postsynaptic potential , chemistry , inhibitory postsynaptic potential , biochemistry , receptor
Hippocampal long‐term potentiation (LTP) is a cellular model of learning and memory. An early form of LTP (E‐LTP) can be reinforced into its late form (L‐LTP) by various behavioral interactions within a specific time window (“behavioral LTP‐reinforcement”). Depending on the type and procedure used, various studies have shown that stress differentially affects synaptic plasticity. Under low stress, such as novelty detection or mild foot shocks, E‐LTP can be transformed into L‐LTP in the rat dentate gyrus (DG). A reinforcing effect of a 2‐min swim, however, has only been shown in (Korz and Frey (2003) J Neurosci 23:7281–7287; Korz and Frey (2005) J Neurosci 25:7393–7400; Ahmed et al. (2006) J Neurosci 26:3951–3958; Sajikumar et al., (2007) J Physiol 584.2:389–400) so far. We have reinvestigated these studies using the same as well as an improved recording technique which allowed the recording of field excitatory postsynaptic potentials (fEPSP) and the population spike amplitude (PSA) at their places of generation in freely moving rats. We show that acute swim stress led to a long‐term depression (LTD) in baseline values of PSA and partially fEPSP. In contrast to earlier studies a LTP‐reinforcement by swimming could never be reproduced. Our results indicate that 2‐min swim stress influenced synaptic potentials as well as E‐LTP negatively. © 2013 Wiley Periodicals, Inc.