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Juvenile, but not adult exposure to high‐fat diet impairs relational memory and hippocampal neurogenesis in mice
Author(s) -
Boitard Chloe,
Etchamendy Nicole,
Sauvant Julie,
Aubert Agnes,
Tronel Sophie,
Marighetto Aline,
Layé Sophie,
Ferreira Guillaume
Publication year - 2012
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22032
Subject(s) - neurogenesis , hippocampal formation , neuroscience , juvenile , hippocampus , psychology , biology , genetics
Increased consumption of high‐fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and adulthood consumption of HFD induce similar morphometric and metabolic changes. However, only juvenile exposure to HFD abolishes relational memory flexibility, assessed after initial radial‐maze concurrent spatial discrimination learning, and decreases neurogenesis. Our results identify a critical period of development covering adolescence with higher sensitivity to HFD‐induced hippocampal dysfunction at both behavioral and cellular levels. © 2012 Wiley Periodicals, Inc.