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Selective facilitation of LTP in the ventral hippocampus by calcium stores
Author(s) -
Grigoryan Gayane,
Korkotian Eduard,
Segal Menahem
Publication year - 2012
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.22000
Subject(s) - long term potentiation , excitatory postsynaptic potential , postsynaptic potential , ryanodine receptor , chemistry , hippocampus , post tetanic potentiation , caffeine , neuroscience , stimulation , facilitation , population , calcium , inhibitory postsynaptic potential , endocrinology , biology , receptor , biochemistry , medicine , environmental health , organic chemistry
The effects of low concentrations of caffeine and ryanodine on field excitatory postsynaptic potentials (EPSPs) and long‐term potentiation (LTP) were studied in CA1 region of slices of dorsal and ventral hippocampus (DH and VH, respectively). There was a striking difference between the two regions in the magnitude of effect of both drugs, as well as the ability to interact with a tetanic stimulation to produce LTP. Low concentration of caffeine (1 mM) produced a postsynaptic increase in the slope of population EPSPs in VH, and facilitated LTP in this region. Low concentration of ryanodine (0.2 μM) was able to convert short‐term potentiation (STP) to LTP in VH only. These effects are postsynaptic and they reflect a higher concentration of ryanodine receptors (RyRs) in the VH compared to the DH. © 2012 Wiley Periodicals, Inc.