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Hippocampal gene profiling: Toward a systems biology of the hippocampus
Author(s) -
Valor Luis M.,
Barco Angel
Publication year - 2012
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20888
Subject(s) - neuroscience , proteomics , profiling (computer programming) , hippocampal formation , computational biology , transcriptome , biology , hippocampus , systems biology , computer science , cognitive science , bioinformatics , psychology , gene expression , gene , genetics , operating system
Transcriptomics and proteomics approaches give a unique perspective for understanding brain and hippocampal functions but also pose unique challenges because of the singular complexity of the nervous system. The proliferation of genome‐wide expression studies during the last decade has provided important insight into the molecular underpinnings of brain anatomy, neural plasticity, and neurological diseases. Microarray technology has dominated transcriptomics research, but this situation is rapidly changing with the recent technological advances in high‐throughput sequencing. The full potential of transcriptomics in the neurosciences will be achieved as a result of its integration with other “‐omics” disciplines as well as the development of novel analytical bioinformatics and systems biology tools for meta‐analysis. Here, we review some of the most relevant advances in the gene profiling of the hippocampus, its relationship with proteomics approaches, and the promising perspectives for the future. © 2010 Wiley Periodicals, Inc.