Interfering with perirhinal brain‐derived neurotrophic factor expression impairs recognition memory in rats | Zendy

Seoane Ana | Zendy; Tinsley Chris J. | Zendy; Brown Malcolm W. | Zendy

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Interfering with perirhinal brain‐derived neurotrophic factor expression impairs recognition memory in rats

Author(s) -

Seoane Ana,

Tinsley Chris J.,

Brown Malcolm W.

Publication year - 2011

Publication title -

hippocampus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 155

eISSN - 1098-1063

pISSN - 1050-9631

DOI - 10.1002/hipo.20763

Subject(s) - perirhinal cortex , neuroscience , psychology , recognition memory , brain derived neurotrophic factor , neurotrophic factors , memory consolidation , temporal lobe , hippocampus , cognition , medicine , receptor , epilepsy

The role of brain‐derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolidation of long‐term (24h) but not shorter‐term (20min) recognition memory. © 2010 Wiley‐Liss, Inc.

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