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Interfering with perirhinal brain‐derived neurotrophic factor expression impairs recognition memory in rats
Author(s) -
Seoane Ana,
Tinsley Chris J.,
Brown Malcolm W.
Publication year - 2011
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20763
Subject(s) - perirhinal cortex , neuroscience , psychology , recognition memory , brain derived neurotrophic factor , neurotrophic factors , memory consolidation , temporal lobe , hippocampus , cognition , medicine , receptor , epilepsy
The role of brain‐derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolidation of long‐term (24h) but not shorter‐term (20min) recognition memory. © 2010 Wiley‐Liss, Inc.